The Role of Electronegative VLDL in Cognitive Dysfunction

Electronegative very-low-density lipoprotein (VLDL) induces cognitive dysfunction and brain inflammation in mice as shown in several studies.

The world’s aging population is increasing rapidly, and the number of individuals with neurodegeneration is increasing as well. Many researchers are seeking to identify the novel pathogenic factors that induce neurodegeneration in people. Prevention is a key objective and a leading public goal.

Alzheimer’s disease (AD) and non-AD dementias are just several examples of neurodegenerative diseases that share similar symptoms, including the relentless progression of cognitive dysfunction, neuronal apoptosis, memory loss, and brain atrophy.

Scientists have previously identified some factors like oxidative stress, neuronal inflammation, and neurotransmitter deficiency. Therapies seek to prevent or delay the onset and progression of neurodegenerative diseases. The form the foundation of current treatment modalities, which primarily lesson symptoms temporarily.

However, much more is needed to actually stop the progression of neurodegeneration in order to improve functionality and quality of life. Therefore, it is critical that studies pinpoint the novel risk factors at play in neurodegeneration.