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LSD-Inroads to Treating Generalized Anxiety Disorder

Sunday, April 28th 2024 10:00am 2 min read
Dr. Jessica Peatross dr.jess.md @drjessmd

Hospitalist & top functional MD who gets to the root cause. Stealth infection & environmental toxicity keynote speaker.

Introduction to a Therapeutic Shift

LSD, traditionally associated with the counterculture of the 1960s, is now making headlines as a potential breakthrough in treating anxiety disorders.

FDA’s Recognition of LSD-Based Treatment

The U.S. Food and Drug Administration (FDA) has recently acknowledged MM120, a new LSD-based drug, by granting it a breakthrough therapy designation for the treatment of generalized anxiety disorder (GAD). This medication, developed by biotech company MindMed, could potentially redefine therapy for millions of anxiety sufferers.

Clinical Trials and Results

MindMed’s recent Phase 2 clinical trials have demonstrated significant potential for MM120 (lysergide d-tartrate). In these trials, a single dosage provided considerable relief: 48% of participants achieved remission at 12 weeks post-treatment, and 65% showed substantial symptom improvement. These results outperform those typically achieved with existing treatments such as cognitive behavioral therapy and various pharmacotherapies.

Expert Insights and Study Highlights

Dr. Daniel Karlin of MindMed, also an assistant professor at Tufts University School of Medicine, highlighted that the observed clinical improvements were notably better than those seen with existing treatments. Importantly, MM120 is administered as a one-time dissolvable tablet without the need for additional psychotherapy—a significant deviation from traditional approaches.

Gabriella Gobbi, a psychedelics researcher at McGill University who did not participate in the trial, emphasized the novelty of treating GAD effectively with a single LSD dose, challenging the belief that psychedelic therapy must always be combined with psychotherapy.

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