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High Homocysteine Levels

Friday, December 16th 2022 10:00am 3 min read
Dr. Jessica Peatross dr.jess.md @drjessmd

Hospitalist & top functional MD who gets to the root cause. Stealth infection & environmental toxicity keynote speaker.

You may have heard about high homocysteine levels, or perhaps your doctor has determined that yours are high. What does this mean? Let’s take a look at the impact of high homocysteine on human health. Specifically, we look at the role of the homocysteine molecule on the cardiovascular system, and what the research says about this.

The homocysteine molecule

What is homocysteine? Homocysteine is a molecule in your blood. This molecule can inform us about things like B12 and folate levels. It’s a reflection of whether or not you are deficient in these vitamins. It’s also a reflection of your overall protein intake and the inflammation occurring in your body. Protein is made up of amino acids. Two of these amino acids are methionine and cystine. Both of these are important precursors and byproducts of homocysteine. If your protein intake levels are low, you will likely have low homocysteine levels.

If you are experiencing inflammation in your body, your homocysteine converts into cysteine to make glutathione. Glutathione can help lower the overall inflammation in your body and neutralize some of that inflammation that’s occurring. However, the most common cause of high homocysteine is a deficiency in B vitamins like B12 and folate.

What happens when homocysteine levels are high?

There are definitely consequences to a deficiency in B12 and folate. Chronic vitamin deficiencies result in negative health conditions. But, let’s look specifically at what happens from the homocysteine molecule. When the homocysteine molecule is elevated, does this molecule have a negative detrimental effect on the body? To understand this, let’s look at the research to understand the relationship between high homocysteine and our health.

What constitutes high homocysteine?

Different laboratories will have different reference ranges for homocysteine. First off you want to make sure to measure your homocysteine in a fasted state, for about 10-12 hours. As far as values, some labs will cut off at 10 micromoles per liter and others will cut it off at 12 or even 15 micromoles per liter. In order to have a designation of hyper-homocystinemia, which is high homocysteine in your blood, your level has to be above 15 micromoles per liter. This is the specific diagnostic criteria for hyper-homocysteinemia.

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