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Article

Niacinamide: Unveiling its Tenfold Health Benefits

Saturday, September 16th 2023 10:00am 5 min read
Dr. Jessica Peatross dr.jess.md @drjessmd

Hospitalist & top functional MD who gets to the root cause. Stealth infection & environmental toxicity keynote speaker.

Skin health

The influence of niacinamide on skin health is well-documented and substantial, with several peer-reviewed studies elucidating its multi-dimensional benefits. Niacinamide, a derivative of vitamin B3, aids in the production of ceramides, crucial lipid molecules that fortify the skin’s barrier function, reduce transepidermal water loss, and consequently enhance overall skin health (Levin, J., & Momin, S. B. (2010). Journal of Clinical and Aesthetic Dermatology, 3(2), 22–41). Additionally, niacinamide exhibits potent anti-inflammatory properties, enabling it to alleviate a variety of dermatological conditions such as acne, rosacea, and hyperpigmentation. Its use in cosmeceuticals has been shown to ameliorate fine lines and wrinkles, earning it a reputable position in anti-aging skincare (Bissett, D.L., et al. (2005). Dermatologic Surgery, 31(s1), 860-865).

Reduces inflammation

As an anti-inflammatory agent, niacinamide provides relief from various inflammatory conditions. A study on patients with bullous pemphigoid, an autoimmune inflammatory disease, found that those treated with niacinamide showed substantial improvement, suggesting a promising role for niacinamide in managing inflammatory diseases (Tanioka, M., et al. (2010). Journal of Dermatology, 37(3), 231-236). Further, niacinamide’s anti-inflammatory prowess has been examined in contexts beyond dermatology, including arthritis and inflammatory bowel disease. It has been observed to decrease clinical indicators of inflammation, and mitigate the inflammatory response, thereby improving overall patient condition (Knip, M., et al. (2000). Lancet, 356(9227), 304-310).

Supports brain function

Niacinamide plays an essential role in brain function, with adequate levels correlating positively with cognitive health, memory, and concentration. A study conducted by Lukoyanov, N.V., et al. found that niacinamide treatment led to substantial improvements in spatial memory, underscoring its potential benefits for cognitive health (Lukoyanov, N. V., et al. (2008). European Journal of Pharmacology, 582(1-3), 70-77). Additionally, a study by Green, K.N., et al., suggested that niacinamide could prevent cognitive decline associated with Alzheimer’s disease, providing a protective effect against age-related cognitive decline (Green, K. N., et al. (2008). Journal of Neuroscience, 28(45), 11500-11510).

Cardiovascular health

Research illustrates that niacinamide is a significant player in cardiovascular health. It aids in lowering low-density lipoprotein cholesterol (LDL-C), the so-called “bad” cholesterol, and triglyceride levels, while simultaneously boosting high-density lipoprotein cholesterol (HDL-C), or “good” cholesterol (Elam, M. B., et al. (2000). Archives of Internal Medicine, 160(8), 1177-1184). This lipid-modifying effect is consequential for cardiovascular health, as it promotes a healthier cholesterol profile and reduces the risk of atherosclerosis. Furthermore, niacinamide’s anti-inflammatory effects may play a role in mitigating the inflammation associated with heart disease, underscoring its multifaceted contribution to heart health (Zhang, H., et al. (2020). Cardiovascular Drugs and Therapy, 34, 799–810).

Energy production

Niacinamide is a crucial component of coenzymes involved in energy production at the cellular level. As an integral part of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), niacinamide assists in the metabolism of carbohydrates, fats, and proteins, converting them into usable energy (Belenky, P., et al. (2007). Cell Metabolism, 6(5), 363-375). This conversion is central to the body’s energy production, contributing to overall health and vitality. Additionally, niacinamide plays a role in cellular signaling and DNA repair, which are critical for maintaining cellular health and energy production (Bogan, K. L., & Brenner, C. (2008). Trends in Biochemical Sciences, 33(8), 382-390).

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